Enzyme Portfolio: Pharmaceutical Applications
Transaminase
Aldo-Keto Reductases
Transaminase
Highly stereoselective synthesis of chiral amines for Sitagliptin production. Enables green-chemistry routes replacing heavy-metal catalysts with excellent enantiomeric excess for anti-diabetic medication.
Nitrilases
Aldo-Keto Reductases
Transaminase
Biocatalytic hydrolysis of nitriles into high-value carboxylic acids under mild pH and temperature conditions. Applications in pharmaceutical and polymer intermediate synthesis.
Aldo-Keto Reductases
Aldo-Keto Reductases
Aldo-Keto Reductases
Enantioselective reduction of carbonyl groups to chiral alcohols using NADPH-dependent pathways. Broad substrate specificity for chiral pharmaceutical intermediate production.
Hydantoinase
Aldo-Keto Reductases
Aldo-Keto Reductases
Hydantoinase Process for non-natural D- and L-amino acid production from racemic precursors. Achieves 100% theoretical yield through optimized ring-opening biocatalysis.
Metabolic Engineering: Sustainable Production
Mannitol Production
Metabolic engineering of microbial strains for the biological production of mannitol, a low-calorie sweetener. Transitioning from chemical hydrogenation to sustainable fermentation and enzymatic conversion of fructose.
- Microbial strain optimization
- Fermentation process development
- Enzymatic fructose conversion
- Scale-up to industrial production
Product Portfolio: Industrial Enzymes
- Nitrilases
Carboxylic acid synthesis
- KREDs
Keto reductases
- Lipases
Ester hydrolysis
- Transaminases
Chiral amine synthesis
- Hydrolases
General biocatalysis